Leonardo da Vinci
1452–1519; born in Vinci near Florence, worked across Florence, Milan, and finally the Loire in France
The archetypal Renaissance polymath — painter of the Mona Lisa and The Last Supper, and a relentless investigator of anatomy, water, flight, optics, and mechanics. Born out of wedlock in Vinci, apprenticed in Florence to Verrocchio, he served the Sforza in Milan and ended his days in France under Francis I. He filled thousands of mirror-written notebook pages with sketches and observations, dissected corpses to understand the body, and left much unfinished — pursuing knowledge for its own sake through direct observation of nature.